BUY AM-1220 ONLINE from our trusted online shop. AM-1220 is a drug that acts as a potent and moderately selective agonist for the cannabinoid receptor CB1, with around 19 times selectivity for CB1 over the related CB2 receptor. The (piperidin-2-yl)methyl side chain of AM-1220 contains a stereocenter, so there are two enantiomers with quite different potency, the (R)-enantiomer having a Ki of 0.27 nM at CB1 while the (S)-enantiomer has a much weaker Ki of 217.
Definition of synthetic cannabinoids
The binding of synthetic cannabinoids to cannabinoid receptors may result in (partial) agonistic, inverse agonistic or antagonistic effects.
Abuse of synthetic cannabinoids (spices)
The abuse of synthetic cannabinoids was first reported in Europe in the early 2000s and in the United States around 2008. However, popularity of recreational use of synthetic cannabinoids are on rapid rise with synthetic cannabinoid related intoxication calls to poison control centers in United Stated increased by 240% between 2010 and 2011.
Compared to natural THC, synthetic cannabinoids are more potent and may have a longer half-life. The effects may appear within 10 min after inhalation and may last 2–6 h after use . Now there are many synthetic cannabinoids found through the Internet but most synthetic cannabinoids detected today can be broadly classified as aminoalkylindoles synthesized by John William Hoffman (JWH-018, JWH-122) or Alexander Makriyannis (AM-2201), cyclohexyl phenols originally synthesized at Pfizer (CP 47,497 and its analogs), benzoyl indoles produced by Research Chemical Suppliers (RCS-4), and classical synthetic cannabinoids such as HU-210 produced at the Hebrew University . Commonly encountered synthetic cannabinoids